NEW U.S. HHS study - Older/Cheaper Drugs Are More Effective

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NEW U.S. HHS study - Older/Cheaper Drugs Are More Effective

Postby NoPocketCash » Wed Sep 05, 2007 11:46 am

The Annals of Internal Medicine (established by the American College of Physicians in 1927) just published a federally funded (Health and Human Services) report on Monday (July 16, 2007) comparing all diabetes medications.

The results do not surprise me.

The newest medications, Avandia and Actos, for which in May, 2007 the FDA requested their most extreme "black box" warning were shown to be less effective than older, cheaper, safer drugs.

216 controlled trials and cohort studies and 2 systematic reviews that addressed benefits and harms of oral diabetes drug classes available in the United States were identified and analyzed.

Besides being just as effective as newer drugs with blood sugar control, Metformin (Glucophage) had another positive effect.
Metformin decreased LDL cholesterol levels by about 0.26 mmol/L (10 mg/dL), whereas other oral agents had no obvious effects on LDL cholesterol levels. Most agents other than metformin increased body weight by 1 to 5 kg. Sulfonylureas and repaglinide were associated with greater risk for hypoglycemia, thiazolidinediones with greater risk for heart failure, and metformin with greater risk for gastrointestinal problems compared with other oral agents. Lactic acidosis was no more common in metformin recipients without comorbid conditions than in recipients of other oral diabetes agents.
Conclusions: Compared with newer, more expensive agents (thiazolidinediones, {alpha}-glucosidase inhibitors, and meglitinides), older agents (second-generation sulfonylureas and metformin) have similar or superior effects on glycemic control, lipids, and other intermediate end points. ... 80-00178v1

Basically this extremely extensive government sponsored study published by a very respected journal says that

Metformin (Glucophage) is better and safer.

This is an important study and you should review the results with your doctor (taking into consideration the drugs you take and the FDA "black box" warnings of Avandia and Actos).

The costs for the extended time-release version of Metformin (Glucophage) from the "drug war" stores is $4 which is often cheaper than the co-pay of most insurance drug plans.
Last edited by dlcnurse on Thu Aug 18, 2011 3:29 am, edited 1 time in total.
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